Members

Lab head

 

מרסל_מחלוף

Professor Marcelle Machluf, Ph.D

Prof. Marcelle Machluf received her Ph.D. in Biotechnology Engineering from the Ben-Gurion University (Israel). Marcelle went on to complete a 5-year post-doctoral fellowship at the Harvard Medical School under the supervision of Prof. Anthony Atalla. Marcelle joined the Technion in 2001, and received tenure in 2007; in 2014, she was promoted to full professor. Prof. Machluf has authored 40 peer-reviewed journal papers, co-authored 15 papers and published over 100 conference papers. Her papers have appeared in leading generalized and specialized journals including Nature Biotechnology, Nano Letters, and Blood, and have been cited over 2,500 times, awarding her an h-index of 26 (Google Scholar). Prof. Machluf has supervised more than 40 graduate and post-doctoral students, from around the world, and is teaching four undergraduate and graduate courses in nano-encapsulation, tissue engineering, mammalian cell technologies, and bioprocessing. Prof. Machluf is a member of the TargetCaRe consortium, under Horizon 2020 Training Networks (H2020-MSCA-ITN-2014). Prof. Machluf is the head of a six-year collaboration between six groups from the Technion and two of Singapore’s leading universities (NTU and NUS) funded by the National Research Foundation of Singapore. Prof. Machluf is a member of the Minerva Programme Committee, under the Max-Planck Institute (Germany) and a member of the Tissue Engineering Journal editorial board. Prof. Machluf is the Head of the Technion’s graduate Interdisciplinary Program in Biotechnology, and was recently appointed as the Deputy Executive Vice President for Research For the Pre-clinical Research Authority of the Technion.

E-mail: machlufm@tx.technion.ac.il

Short C.V.

Google Scholar profile

PUBMED citations

PUBLICATIONS


Management


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Dr. Limor Baruch, Ph.D.

Dr. Limor Baruch, Senior research fellow, co-lab manager and Tissue Engineering and cell-based therapy group leader. Limor received her Ph.D. in Biotechnology Engineering from the Technion, under the supervision of Prof. Machluf. Limor’s dissertation presented the development of two cell- microencapsulation platforms and their application for cancer treatment. In 2008, Dr. Baruch established the laboratory for crop quality at Kaiima Bio-Agritech Ltd., and managed it for six years. Dr. Baruch expertise includes the setup of laboratories and research fields, diverse analytical methodologies and scientific consultancy in addition to cell-based therapy, drug delivery systems and regenerative medicine. E-mail: baruchl@bfe.technion.ac.il


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Ms. Inna Kovrigina, M.Sc, Lab technician. E-mail: inna.ko777@gmail.com (profile under construction)


Post & Graduate Students


Dr. Anton Zernov, Ph.D, postdoc

Anton completed his M.Sc and Ph.D in bioengineering and biotechnology in the Faculty of Biology, M.V.Lomonosov Moscow State University, and Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Science. Now he is currently a postdoc. His research focuses on the development and investigation of mesenchymal stem cells membrane-derived nanoghosts with encapsulated gold nanoparticles for diagnostics and photodynamic therapy of cancer. Also, his interests include the development and investigation of clean meat.

E-mail: zernovanton89@gmail.com


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Noa Cohen, M.Sc, Ph.D student

Noa completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an MSc student. Her research focuses on a novel drug delivery system aimed to target brain cancer across the Blood-Brain Barrier (BBB) using nano-vesicles derived from Mesenchymal stem cells (MSCs) which are known for their targeting abilities towards wounds and inflammation and have been shown to migrate across the BBB. MSCs derived vesicles (nano-ghosts) may serve as an effective drug delivery system for targeting brain inflammation and cancer.
E-mail:
 noacoh@gmail.com


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Natali Malkah Dayan, M.Sc, Ph.D student

Natali completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an M.Sc student. Her research focuses on a novel drug delivery system, Nano-Ghosts (NGs), aimed to selectively target lung cancer metastases while delivering therapeutic drugs. The NGs are nano-vesicles produced from the plasma membrane of human mesenchymal stem cells (hMSCs), known for their natural targeting of multiple cancers and hypo-immunogenicity. Different anti-cancer agents are encapsulated within the NGs system, such as Cisplatin, and their therapeutic index will be evaluated in vitro and in vivo.
E-mail: natalid24@gmail.com


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Stasia Krishtul, M.Sc, Ph.D student

Stasia completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an MSc student. Her research focuses on a novel encapsulation platform for diabetes therapy. In this platform, insulin secreting cells are entrapped within microcapsules based on natural pancreatic ECM hydrogel, which provides the cells a natural fibrous niche that supports their viability and biological functionality.
E-mail: technionstasia@gmail.com


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Domenico D’atri, M.Sc., Ph.D student

Domenico completed his M.Sc in Industrial and Molecular Biotechnology in the Faculty of Mathematical, Physical and Natural Sciences of the University of Pisa , and is currently a PhD student. His research work is the production of Nano-Ghosts (NGs) from mesenchymal stem cells for targeting cartilage tissue regeneration. His aim is to entrap different therapeutics (e.g growth factors, antibiotics, corticosteroids, etc.) in the NGs, and study their targeting and therapeutic efficacy in vitro and in vivo. 
E-mail: domenicodatri88@gmail.com


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Jacopo Oieni, M.Sc., Ph.D student

Jacopo completed his B.Sc and M.Sc in Pharmaceutical Biotechnology at University of Pavia (Italy), and is currently a PhD student.His research focuses on the development of a novel targeted non-viral delivery system for RNA interference, which is based on nano-ghosts produced from the cell membrane of mesenchymal stem cells, for Osteoarthritis treatment. The aim of his project is to encapsulate therapeutics siRNA and miRNA molecules for cartilage regeneration and investigate their efficacy both in vitro and in vivo

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Lior Levy, M.Sc., Ph.D student

Lior completed his B.Sc. and his M.Sc. in synthetic biology in the Faculty of Biotechnology and Food Engineering at the Technion, and is currently a Ph.D. student. His research focuses on combining the immune system properties with the novel drug delivery system, Nano-Ghosts (NGs). Lior is also investigating the safety and efficacy of such system in-vitro and in-vivo.


 

Tzila Davidov, M.Sc, Ph.D student

Tzila completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an MSc student. Her research focuses on the effect of the ECM origin in structuring 3D models, and its influence on the function and the differentiation of cells, such as induced pluripotent stem cells (hiPSCs) into the desired cell and tissue type.
E-mail: tzila937@gmail.com

 


 

Avraham Fridman, M.Sc, Ph.D. student

Avraham completed his B.Sc. in Pharmaceutical Engineering at the Azrieli College of Engineering Jerusalem, completed his M.Sc. in Pharmaceutical Sciences at the Hebrew University of Jerusalem and is currently a Ph.D. student. His research focuses on the applications of Nano-Ghosts from mesenchymal stem cells for inflammation therapy and as a drug delivery system with the capacity to pass across the blood-brain-barrier (BBB) targeting brain inflammation.

E-mail: favremi89@gmail.com


Rotem Hayam, B.Sc, M.Sc student

Rotem completed her B.Sc in the Faculty of Chemistry Engineering at the Technion and is currently an MSc student. Her research focuses on the development of advanced Extracellular Matrix processing technologies for Tissue Engineering.

E-mail: rotemh27@gmail.com


Michal Skitel, B.Sc, M.Sc student

Michal completed her B.Sc in Biotechnology at the Hadassah Academic College and is currently an M.Sc. Student. Her Research focuses on Extracellular Matrix (ECM) based therapy for diabetes. In this research, the ECM is engineered as microcapsules to support islets viability.

E-mail: michalsk@campus.technion.ac.il


 

Shani Hamias, M.Sc student

Shani completed her B.Sc in the Faculty of Chemistry Engineering at the Technion and is currently an MSc student. Her research focuses on a novel drug delivery system aimed to selectively target brain cancer across the Blood-Brain Barrier (BBB) using MSCs derived vesicles (nano-ghosts).

E-mail: shanihm17@gmail.com