Professor Marcelle Machluf, Ph.D
Prof. Marcelle Machluf received her Ph.D. in Biotechnology Engineering from the Ben-Gurion University (Israel). Marcelle went on to complete a 5-year post-doctoral fellowship at the Harvard Medical School under the supervision of Prof. Anthony Atalla. Marcelle joined the Technion in 2001, and received tenure in 2007; in 2014, she was promoted to full professor. Prof. Machluf has authored 40 peer-reviewed journal papers, co-authored 15 papers and published over 100 conference papers. Her papers have appeared in leading generalized and specialized journals including Nature Biotechnology, Nano Letters, and Blood, and have been cited over 2,500 times, awarding her an h-index of 26 (Google Scholar). Prof. Machluf has supervised more than 40 graduate and post-doctoral students, from around the world, and is teaching four undergraduate and graduate courses in nano-encapsulation, tissue engineering, mammalian cell technologies, and bioprocessing. Prof. Machluf is a member of the TargetCaRe consortium, under Horizon 2020 Training Networks (H2020-MSCA-ITN-2014). Prof. Machluf is the head of a six-year collaboration between six groups from the Technion and two of Singapore’s leading universities (NTU and NUS) funded by the National Research Foundation of Singapore. Prof. Machluf is a member of the Minerva Programme Committee, under the Max-Planck Institute (Germany) and a member of the Tissue Engineering Journal editorial board. Prof. Machluf is the Head of the Technion’s graduate Interdisciplinary Program in Biotechnology, and was recently appointed as the Deputy Executive Vice President for Research For the Pre-clinical Research Authority of the Technion.
Dr. Tomer Bronshtein, Ph.D
Dr. Tomer Bronshtein is the manager of Prof. Machluf’s lab and is concentrating all data analysis, academic writing, and exploitation efforts of the nano-ghosts technology. Tomer received his Ph.D. in Biotechnology Engineering from the Technion, under the supervision of Prof. Machluf. The pivotal concept of using nano-ghosts for drug delivery was the subject of Tomer’s dissertation, aimed for treating HIV/AIDS. Dr. Bronshtein undertook a 3-year post-doctoral position in the Nanyang Technological University (Singapore) under the supervision of leading material scientists Subbu Venkatraman and Freddy Boey. During his fellowship, Dr. Bronshtein focused on developing MSC-based cardiac restoration therapies. Dr. Bronshtein specializes in drug delivery and mathematical computer-aided modeling of biological systems for regenerative medicine. E-mail: email@example.com
Dr. Limor Baruch, Ph.D.
Dr. Limor Baruch, Senior research fellow, co-lab manager and Tissue Engineering and cell-based therapy group leader. Limor received her Ph.D. in Biotechnology Engineering from the Technion, under the supervision of Prof. Machluf. Limor’s dissertation presented the development of two cell- microencapsulation platforms and their application for cancer treatment. In 2008, Dr. Baruch established the laboratory for crop quality at Kaiima Bio-Agritech Ltd., and managed it for six years. Dr. Baruch expertise includes the setup of laboratories and research fields, diverse analytical methodologies and scientific consultancy in addition to cell-based therapy, drug delivery systems and regenerative medicine. E-mail: firstname.lastname@example.org
Ms. Inna Kovrigina, M.Sc, Lab technician. E-mail: email@example.com (profile under construction)
Post & Graduate Students
Yael Efraim, Ph.D., Post doctoral Fellow
Yael Efraim, B.Sc is currently a Post doctoral fellow at the Faculty of Biotechnology and Food Engineering at the Technion- Israel Institute of Technology. Yael’s research is in the field of tissue engineering, where it combines scaffold design and in-vitro cell culture. Her work focuses on injectable biological scaffolds and induced pluripotent stem cells (IPSC) for minimally invasive cell delivery to treat Myocardial Infarction.
Maskit Gvirtz, M.Sc, Ph.D student
Maskit Gvirtz with a B.Sc in Biomedical Engineering is a Ph.D student at Biotechnology and food engineering as well as a teaching assistant at the Faculty in the Technion- Israel Institute of Technology. Her goal is to design and study a mechanical- electrical stimulation apparatus for extra cellular matrix (ECM) thick cardiac tissue. In order to do so, she designed a computer integrated system that stimulates a left ventricle decellularized tissue, using an inflating/deflating balloon for mechanical stimulation, and a computer made signal transferred to a set of electrodes as an electrical stimulation. The computer can control the rhythm, volume of the mechanical stimulation, electrical signal shape and the synchronization between the two stimulations. The next stage is to study the effect of the system on different types of cells such as mesenchymal stem cells, cardiomyocytes etc. In order to improve, cell confluents, cell penetration depth into the tissue, cell growth, tissue tensile strength, cell organization, and unity in electrical conductivity. Controlling different aspects of cell growth on cardiac tissue will promote research of tissue engineering, and eventually, replacing organs with a non immunogenic lab made heart.
Nitzan Letko, M.Sc, Ph.D student
Nitzan completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion, and is currently a PhD student. She focuses on a novel drug delivery system – termed Nano Ghosts (NG), which is based on nano-vesicles produced from the plasma membrane of human Mesenchymal Stem Cells (MSCs), known for their targeting abilities towards wounds and inflammation. As a target she uses models of inflammation, attempting to encapsulate therapeutic agents and test their delivery and effect both in vitro and in vivo.
Noa Cohen, M.Sc, Ph.D student
Noa completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an MSc student. Her research focuses on a novel drug delivery system aimed to target brain cancer across the Blood-Brain Barrier (BBB) using nano-vesicles derived from Mesenchymal stem cells (MSCs) which are known for their targeting abilities towards wounds and inflammation and have been shown to migrate across the BBB. MSCs derived vesicles (nano-ghosts) may serve as an effective drug delivery system for targeting brain inflammation and cancer.
Natali Malkah Dayan, M.Sc, Ph.D student
Natali completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an M.Sc student. Her research focuses on a novel drug delivery system, Nano-Ghosts (NGs), aimed to selectively target lung cancer metastases while delivering therapeutic drugs. The NGs are nano-vesicles produced from the plasma membrane of human mesenchymal stem cells (hMSCs), known for their natural targeting of multiple cancers and hypo-immunogenicity. Different anti-cancer agents are encapsulated within the NGs system, such as Cisplatin, and their therapeutic index will be evaluated in vitro and in vivo.
Stasia Krishtul, B.Sc, Ph.D student
Stasia completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an MSc student. Her research focuses on a novel encapsulation platform for diabetes therapy. In this platform, insulin secreting cells are entrapped within microcapsules based on natural pancreatic ECM hydrogel, which provides the cells a natural fibrous niche that supports their viability and biological functionality.
Domenico D’atri, M.Sc., Ph.D student
Domenico completed his M.Sc in Industrial and Molecular Biotechnology in the Faculty of Mathematical, Physical and Natural Sciences of the University of Pisa , and is currently a PhD student. His research work is the production of Nano-Ghosts (NGs) from mesenchymal stem cells for targeting cartilage tissue regeneration. His aim is to entrap different therapeutics (e.g growth factors, antibiotics, corticosteroids, etc.) in the NGs, and study their targeting and therapeutic efficacy in vitro and in vivo.
Jacopo Oieni, M.Sc., Ph.D student
Lior Levy, M.Sc., Ph.D student
Lior completed his B.Sc. and his M.Sc. in synthetic biology in the Faculty of Biotechnology and Food Engineering at the Technion, and is currently a Ph.D. student. His research focuses on combining the immune system properties with the novel drug delivery system, Nano-Ghosts (NGs). Lior is also investigating the safety and efficacy of such system in-vitro and in-vivo.
Muthu Kumar Krishnamoorthi, M.Tech., PhD Student
Muthu completed his M.Tech. in Medical Nanotechnology from SASTRA University, India and is currently a Joint PhD student with Technion, Israel and NTU, Singapore. His work focuses on the engineering of 3 dimensional scaffolds for cardiac tissue regeneration with polymers and natural ECM materials.
Tzila Davidov, B.Sc, M.Sc student
Tzila completed her B.Sc in the Faculty of Biotechnology and Food Engineering at the Technion and is currently an MSc student. Her research focuses on the effect of the ECM origin in structuring 3D models, and its influence on the function and the differentiation of cells, such as induced pluripotent stem cells (hiPSCs) into the desired cell and tissue type.
Sharbel Zahran, B.Sc, M.Sc student
Sharbel received his B.Sc in Biotechnology and Food Engineering from the Technion and currently is an M.Sc. student. His work focuses on developing electrospun scaffolds fabricated from natural biomaterials as biomimetic devices. Currently, his main aim is the development and assessment of cardiac ECM electrospun scaffold as a treatment for myocardial infraction.