2015 – to date

Research papers

  • Oieni, J.*, Levy, L.*, Letko Khait, N., Yosef, L., Schoen, B., Fliman, M., Shalom-Luxenburg, H., Malkah Dayan, N., D’Atri, D., Cohen Anavy, N., Machluf, M. “Nano-Ghosts: Biomimetic membranal vesicles, technology and characterization”. Methods 177, 126–134.2020.*Equal contribution.

  • Cristea, D.*, Krishtul, S.*, Kuppusamy, P., Baruch, L., Machluf, M., Blank, A. “New approach to measuring oxygen diffusion and consumption in encapsulated living cells, based on electron spin resonance microscopy”. Acta Biomaterialia, 2019. *Equal contribution.

  • Lupu-Haber, Y., Bronshtein, T., Shalom-Luxenburg, H., D’Atri, D., Oieni, J., Kaneti, L., Shagan, A., Hamias, S, Amram, L., Kaneti, G., Cohen Anavy, N., Machluf, M. “Pretreating Mesenchymal Stem Cells with Cancer Conditioned-Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells”. Advanced Healthcare Materials. 1801589. 2019.

  • Krishtul, S., Baruch, L., Machluf, M. “Processed Tissue–Derived Extracellular Matrices: Tailored Platforms Empowering Diverse Therapeutic Applications”. Adv. Funct. Mater.  1900386, 2019.

  • Goldfracht, I., Efraim, Y., Shinnawi, R., Kovalev, E., Huber, I., Gepstein, A., Arbel, G., Shaheen, N., Tiburcy, M., Zimmerman, W.H., Machluf, M., Gepstein, L. “Engineered Heart Tissue Models from hiPSC-Derived Cardiomyocytes and Cardiac ECM for Disease Modeling and Drug Testing Applications”. Acta Biomater, 2019.

  • Efraim, Y., Schoen, B., Zahran, S., Davidov, T., Vasilyev, G., Baruch, L., Zussman, E., Machluf, M.   “3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds”. Sci Rep , 9(1):5578, 2019.

  • Letko Khait, N., Malkah, N., Kaneti, G., Fried, L., Cohen Anavy, N., Bronshtein, T., & Machluf, M. “Radiolabeling of cell membrane-based nano-vesicles with 14C-linoleic acid for robust and sensitive quantification of their biodistribution”. Journal of Controlled Release, 293, 215–223, 2019.

  • Timaner, M. N. Letko-Khait,  R. Kotsofruk, M. Benguigui, O. Beyar-Katz, C. Rachman-Tzemach, Z. Raviv, T. Bronshtein, M. Machluf, and Y. Shaked.  “Therapy-Educated Mesenchymal Stem Cells Enrich for Tumor Initiating Cells.” Cancer Research, 78, 1253–1265, 2018.

  • Sarig, H. Sarig, A. Gora, M. K. Krishnamoorthi, G.C.T Au-Yeung, E. de-Berardinis, S.Y Chaw, P. Mhaisalkar, H. Bogireddi, S. Ramakrishna, F.Y.C Boey, S. Venkatraman, M. Machluf. Biological and Mechanical Interplay at the Macro- and Microscales Modulates the Cell-Niche Fate. Scientific Reports 8 (1): 3937. 2018.

  • Schoen, R. Avrahami, L. Baruch, Y. Efraim, I. Goldfracht, O. Elul, T. Davidov, L. Gepstein, E. Zussman, M. Machluf. Electrospun Extracellular Matrix: Paving the Way to Tailor-Made Natural Scaffolds for Cardiac Tissue Regeneration. Advanced Functional Materials, 1700427, 2017.

  • Au-Yeung, U. Sarig, H. Sarig, H. Bogireddi, T. Bronshtein, L. Baruch, A. Spizzichino, J. Bortman, B.Y.C. Freddy, M. Machluf, S.S. Venkatraman. Restoring the biophysical properties of decellularized patches through recellularization. Biomaterials Science, 5(6):1183-1194, 2017.

  • Haber, L. Baruch, M. Machluf. Ultrasound-Mediated Mesenchymal Stem Cells Transfection as a Targeted Cancer Therapy Platform. Scientific Reports, 7:42046, 2017.

  • Dahan, U. Sarig, L. Baruch, T. Bronshtein, T. Karram, A. Hoffman, M. Machluf. Dynamic Autologous Re-endothelialization of Small Caliber Arterial Extracellular Matrix: a Preclinical Large Animal Study. Tissue Engineering Part A, 23(1-2):69-79, 2017.

  • Efraim, H. Sarig, N. Cohen Anavy, U. Sarig, E.D. Berardinis, S. Chaw, M. Krishnamoorthi, J. Kalifa, H. Bogireddi, T.V. Duc, T. Kofidis, L. Baruch, Y.C.F. Boey, S.S. Venkatraman, M. Machluf. Biohybrid Cardiac ECM-Based Hydrogels Improve Long Term Cardiac Function Post Myocardial Infarction. Acta Biomaterialia, 50:220-233, 2016.

  • Sarig, H. Sarig, H. de-Berardinis, S. Chaw, E.B.V. Nguyen, V. S. Ramanujam, V. D. Thang, M. Al-Haddawi, S. Liao, D. Seliktar, T. Kofidis, F.Y.C. Boey, S.S. Venkatraman, M. Machluf. Natural myocardial ECM Patch Drives Cardiac Progenitor Based Restoration Even After Scarring. Acta Biomaterialia, 44:209-220, 2016.

  • Chaimov, L. Baruch, S. Krishtul, I. Meivar-Levy, S. Ferber, M. Machluf. Innovative encapsulation platform based on pancreatic extracellular matrix achieve substantial insulin delivery. Journal of Controlled Release, 16:30491-6, 2016.

  • Gilert, A., Baruch, L., Bronshtein, T, & Machluf, M., PLGA-Listeriolysin O microspheres: Opening the gate for cytosolic delivery of cancer antigens. Biomedical microdevices 18 (2), 1-10, 2016.

  • Kaneti, L., Bronshtein, T., Malkah Dayan, N., Kovregina, I., Letko Khait, N., Lupu-Haber, Y., Fliman, M., Schoen, B., Kaneti, G., & Machluf, M. Nano-ghosts as a novel natural non-viral gene delivery platform safely targeting multiple cancers. Nano Letters 16 (3), 1574–1582, 2016.

  • Voloshin, T., Alishekevitz, D., Kaneti, L., Miller, V., Isakov, E., Kaplanov, I., Voronov, E., Fremder, E., Benhar, M., Machluf, M., Apte, R.N. & Shaked, Y. Blocking IL1beta Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis. Molecular cancer therapeutics 14, 1385-1394, 2015.

  • Shivinsky, A., Bronshtein, T., Haber, T. & Machluf, M. The effect of AZD2171- or sTRAIL/Apo2L-loaded polylactic-co-glycolic acid microspheres on a subcutaneous glioblastoma model. Biomedical microdevices 17, 69, 2015.

  • Sarig, U., Nguyen, E.B., Wang, Y., Ting, S., Bronshtein, T., Sarig, H., Dahan, N., Gvirtz, M., Reuveny, S., Oh, S.K., Scheper, T., Boey, Y.C., Venkatraman, S.S. & Machluf, M. Pushing the envelope in tissue engineering: ex vivo production of thick vascularized cardiac extracellular matrix constructs. Tissue engineering. Part A 21, 1507-1519, 2015.

  • Irvine, S.A., Agrawal, A., Lee, B.H., Chua, H.Y., Low, K.Y., Lau, B.C., Machluf, M. & Venkatraman, S. Printing cell-laden gelatin constructs by free-form fabrication and enzymatic protein crosslinking. Biomedical microdevices 17, 16, 2015.